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中生网 > 生物资讯 > 科研进展 > Hepatology适量摄入咖啡因或能防治脂肪肝

Hepatology适量摄入咖啡因或能防治脂肪肝

更新:2013年12月21日 阅读次数: 【字体:

咖啡或茶中含有咖啡因,很多人知道它可以缓解疲劳、驱走睡意。最新研究表明,适度摄入咖啡因还可能降低一类常见脂肪肝的风险。

该研究由美国杜克大学医学院等机构进行。通过细胞培养实验和以高脂膳食喂养的小鼠进行动物实验,研究人员发现,咖啡和茶中所含的咖啡因能刺激肝细胞内堆积的脂类新陈代谢,并有效降低小鼠的脂肪肝程度。

最终结果表明,人体如果每天摄入四杯左右的咖啡或茶,其所含的咖啡因对防治非酒精性脂肪肝(NAFLD)可能颇有益处。

非酒精性脂肪肝是指并非过度饮酒而导致的肝脏内脂肪堆积。据估计,世界上70%的糖尿病和肥胖症患者都患有非酒精性脂肪肝,除了体育锻炼和健康饮食之外,目前尚没有特效疗法。

研究者说,这是首次就咖啡因对肝脏脂类的作用机制进行的细致研究,或许可以成为充分开发咖啡因益处与医疗价值研究的起点。研究结果将会发布在九月份的《肝脏病学》杂志上。

推荐的英文摘要

Hepatology适量摄入咖啡因或能防治脂肪肝

Hepatology               DOI: 10.1002/hep.26667

Caffeine stimulates hepatic lipid metabolism via autophagy-lysosomal pathway

Rohit Anthony Sinha1, Benjamin L. Farah1, Brijesh K. Singh1, Monowarul Mobin Siddique1, Ying Li1, Yajun Wu2, Olga R. Ilkayeva3, Jessica Gooding3, Jianhong Ching1, Jin Zhou1, Laura Martinez1, Sherwin Xie1, Boon-Huat Bay2, Scott A. Summers1,3, Christopher B. Newgard3, Paul M. Yen1,3,*

Caffeine is one of the world's most consumed drugs. Recently, several studies showed that its consumption is associated with lower risk for non-alcoholic fatty liver disease (NAFLD), an obesity-related condition that recently has become the major cause of liver disease worldwide. Although caffeine is known to stimulate hepatic fat oxidation, its mechanism of action on lipid metabolism is still not clear. Here, we show that caffeine surprisingly is a potent stimulator of hepatic autophagic flux. Using genetic, pharmacological, and metabolomic approaches, we demonstrate that caffeine reduces intra-hepatic lipid content and stimulates β-oxidation in hepatic cells and liver via an autophagy-lysosomal pathway. Furthermore, caffeine induced autophagy involved down-regulation of mTOR signaling and alteration in hepatic amino acids and sphingolipid levels. In mice fed a high fat diet, caffeine markedly reduces hepatosteatosis and concomitantly increases autophagy and lipid uptake in lysosomes. Conclusion: Taken together, these results provide novel insight into caffeine's lipolytic actions through autophagy in mammalian liver and its potential beneficial effects in NAFLD.

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