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中生网 > 生物资讯 > 科研进展 > 赖仞等从蛙类皮肤中发现强效促皮肤创伤修复肽

赖仞等从蛙类皮肤中发现强效促皮肤创伤修复肽

更新:2014年03月02日 阅读次数: 【字体:

2月24日,记者从中科院昆明动物研究所获悉,为研究减少慢性皮肤溃疡的发病率、降低其致残率、死亡率,该所研究员赖仞课题组从无指盘臭蛙皮肤中鉴定出一条强效促皮肤创伤修复肽,希望能开发出安全、低毒、高效的促皮肤愈合候选药物。该研究成果发表在《国际生物化学与分子生物学》杂志上。

据介绍,皮肤作为生物体抵御外界环境侵害的第一道防线,起着至关重要的屏障作用。与此同时,皮肤也成为最容易受到外界损伤的组织器官。

慢性皮肤溃疡又称难治性溃疡,多见于老年人,尤其是在合并有糖尿病、脉管炎和下肢静脉回流障碍的老年人群中更为常见。随着人口的老龄化趋势和糖尿病、心血管疾病等发病率的增高,慢性皮肤溃疡的发病率明显上升。有报道称,约15%的老年人遭受慢性皮肤创伤的困扰。慢性皮肤溃疡迁延难治、预后差,严重影响患者的身体状况和生活质量,其治疗已引起国内外学者的广泛关注。

为此,赖仞课题组,从无指盘臭蛙皮肤中鉴定了一条强效促皮肤创伤修复肽,命名为AH90。在小鼠全层皮损模型中,AH90表现出强烈的促创伤愈合活性。该小肽能促进内源性促创伤愈合因子的表达而不产生促有丝分裂活性,因此科研人员认为,AH90有希望开发为一个良好的促创伤愈合候选药。

赖仞等从蛙类皮肤中发现强效促皮肤创伤修复肽

推荐的英文摘要:

The International Journal of Biochemistry & Cell Biology

 doi:10.1016/j.biocel.2014.01.010

A potential wound healing-promoting peptide from frog skin

Han Liua, e, 1, Lixian Mua, e, 1, Jing Tanga, e, 1, Chuanbin Shena, e, Chen Gaod, Mingqiang Ronga, Zhiye Zhanga, e, Jie Liua, e, Xiaoyang Wuc, Haining Yub, , , Ren Laia,

Cutaneous wound healing is a dynamic, complex, and well-organized process that requires the orchestration of many different cell types and cellular processes. Transforming growth factor β1 is an important factor that plays a key role during wound healing. Amphibian skin has been proven to possess excellent wound healing ability, whilst no bioactive substrate related to it has ever been identified. Here, a potential wound healing-promoting peptide (AH90, ATAWDFGPHGLLPIRPIRIRPLCG) was identified from the frog skin of Odorrana grahami. It showed potential wound healing-promoting activity in a murine model with full thickness dermal wound. AH90 promoted release of transforming growth factor β1 through activation of nuclear factor-κB and c-Jun NH2-terminal kinase mitogen-activated protein kinases signaling pathways, while inhibitors of nuclear factor-κB and c-Jun NH2-terminal kinase inhibited the process. In addition, the effects of AH90 on Smads family proteins, key regulators in transforming growth factor β1 signaling pathways, could also be inhibited by transforming growth factor β1 antibody. Altogether, this indicated that AH90 promoted wound healing by inducing the release of transforming growth factor β1. This current study may facilitate the understanding of effective factors involved in the wound repair of amphibians and the underlying mechanisms as well. Considering its favorable traits as a small peptide that greatly promoting generation of endogenous wound healing agents (transforming growth factor β1) without mitogenic effects, AH90 might be an excellent template for the future development of novel wound-healing agents.

 

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